Augmentin causes the death of facultative flora and blocks the biosynthesis of the cell membrane, which performs structural, protective and transport functions. Amoxicillin combined with clavulanic acid enhances bactericidal activity of segmented neutrophils, which play a very important role in protecting the body from infections of bacterial and fungal etiology. Clavulanic acid stimulates the adhesion and motor reaction of neutrophils (leukocytes) to a chemical stimulus.
Pharmacology of amoxicillin
Amoxicillin is destroyed by penicillinase. Antibiotic is resistant to acidic environment. Its target is the bacterial enzyme glycopeptidranspeptidase. The antimicrobial agent inhibits the synthesis of murein, which performs antigenic and mechanical functions of the osmotic protection of the cell.
Pharmacology of clavulanic acid
Clavulanate has its own antimicrobial activity. The inhibitor is sensitive to Pseudomonas aeruginosa and Enterococcus (minimal activity); Haemophilus influenzae and Enterobacteriaceae (moderate activity); Bacteroides, Moraxella, Staphylococcus, Streptococcus, Neisseria gonorrhoeae, Chlamydia trachomatis and Legionella (high activity). Like other β-lactam antibiotics, clavulanic acid interacts with penicillin-binding proteins of gram + and gram-drivers and promotes dissolution of the cell membrane.
These pharmacokinetics were obtained in experimental and laboratory studies in volunteers after taking on an empty stomach.
The rapidity of achieving an effective concentration of drugs in the plasma
The drug is rapidly and completely absorbed from the digestive tract. Absorption of active ingredients Augmentin is optimal in case of its intake before meals. The time to reach the maximum concentration is 3/4 hours.
Distribution Lec. Means in the body
Therapeutic concentrations of amoxicillin and clavulanate are formed in the organs of the chest and abdominal cavity, adipose tissue, bones, muscles, bile, serous-purulent discharge and fluids: pleural, produced pleura, synovial, invading joint, peritoneal, responsible for moistening the abdominal wall, and tissue , Contained in the cell circumferences. The degree of binding to plasma proteins is low (no more than thirty percent for both substances).
Metabolism and elimination
The antibiotic is eliminated by the kidneys (glomerular filtration and tubular secretion). After 1-time oral intake, both substances are excreted from the body in six hours. The half-life period depends on the dose, the average value is one hour.